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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
57.88
Human Site:
Y418
Identified Species:
84.89
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
Y418
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
Y409
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
Y418
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Dog
Lupus familis
XP_541736
1001
113024
Y516
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
Y418
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Rat
Rattus norvegicus
NP_001101343
905
102125
Y419
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
Y425
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Chicken
Gallus gallus
NP_001006139
888
100332
Y405
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Frog
Xenopus laevis
P55861
886
100243
Y403
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
Y397
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
Y403
E
L
E
V
T
G
I
Y
T
N
N
Y
D
G
S
Honey Bee
Apis mellifera
XP_395109
1005
114136
Y522
E
V
D
V
T
A
I
Y
T
N
N
Y
D
G
S
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
G344
S
I
A
P
S
I
Y
G
S
A
D
I
K
K
S
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
Y403
E
I
E
L
T
G
V
Y
N
N
N
Y
D
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
V353
K
S
Q
L
L
R
A
V
M
N
I
A
P
L
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
Y430
E
V
E
V
T
G
I
Y
K
N
N
Y
D
G
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
80
66.6
13.3
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
86.6
26.6
100
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
13.3
N.A.
N.A.
73.3
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
93.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
7
7
0
0
7
0
7
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
0
0
0
0
0
7
0
88
0
0
% D
% Glu:
88
0
82
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
82
0
7
0
0
0
0
0
88
0
% G
% His:
0
0
0
0
0
0
0
0
63
0
0
0
0
0
0
% H
% Ile:
0
75
0
0
0
7
82
0
0
0
7
7
0
0
0
% I
% Lys:
7
0
0
0
0
0
0
0
7
0
0
0
7
7
0
% K
% Leu:
0
7
0
75
7
0
0
0
0
0
0
0
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
7
94
88
0
0
0
7
% N
% Pro:
0
0
0
7
0
0
0
0
0
0
0
0
7
0
0
% P
% Gln:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% R
% Ser:
7
7
0
0
7
0
0
0
7
0
0
0
0
0
88
% S
% Thr:
0
0
0
0
88
0
0
0
13
0
0
0
0
0
0
% T
% Val:
0
13
0
19
0
0
7
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
88
0
0
0
88
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _